Reid W von Borstel Selected Research

uridine triacetate

1/2018	Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency.
1/2017	Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity.
12/2006	Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.
12/2005	Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine.
12/2003	Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Reid W von Borstel Research Topics

Disease

2	Dihydropyrimidine Dehydrogenase Deficiency 01/2018 - 01/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2006 - 12/2005
2	Huntington Disease (Huntington's Disease) 12/2006 - 12/2003
1	Diarrhea 01/2017
1	Mucositis 01/2017
1	Cardiotoxicity 01/2017
1	Leukopenia 01/2017
1	Nausea 01/2017
1	Neoplasms (Cancer) 01/2017
1	Vomiting 01/2017
1	Hypoxia (Hypoxemia) 12/2005
1	Weight Loss (Weight Reduction) 12/2003
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2003

Drug/Important Bio-Agent (IBA)

5	uridine triacetateIBA 01/2018 - 12/2003
4	ProdrugsIBA 01/2018 - 12/2003
3	UridineIBA 12/2006 - 12/2003
2	Fluorouracil (Carac)FDA LinkGeneric 01/2018 - 01/2017
2	Capecitabine (Xeloda)FDA Link 01/2018 - 01/2017
2	3-nitropropionic acidIBA 12/2006 - 12/2003
1	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 01/2018
1	EnzymesIBA 01/2017
1	PyrimidinesIBA 12/2003
1	pyrimidineIBA 12/2003
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 12/2003
1	Neuroprotective AgentsIBA 12/2003

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2017